|
KMID : 0372919880090010037
|
|
Journal of Biomedical Engineering Research
1988 Volume.9 No. 1 p.37 ~ p.45
|
|
|
Synthesis and Physical Properties of Biodegradable Polymers -Poly (glycine-co- lactic acid) and Poly (glycine-co- glycolic acid)-
|
|
|
|
|
Abstract
|
|
|
|
Synthetic biodegradable polymers are of great interest for biomedical applications such as surgical sutures and drug delivery systems. The copolymers of a-amino acids and a-hydroxy matrices having the required permeability for drugs. Poly (glycine.co-lactic acid) and poly (glycine-co-glycolic acid) have been synthesized by ring-opening polymerization. Morpholine-2,5-diane, lactide, and glycolid have been used as starting materials for polydepsipeptides. The synthesized monomers and copoylmers have been identified by NMR and FT-lR spectrophotometer. The thermal properties and glass transition temperatures (Tg) of the copolymers have been measured by differential scanning calorimetry. The Tg values of poly (glycine-co-lactic acid) and poly (glycine co.glycolic acid) are increased with increasing mole fraction of morpholine-2,5-dione in the copolymers.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|